Descovy for HIV PrEP is covered by Medicare Part B
Since September 30, 2024, Medicare Part B covers FDA-approved drugs for HIV pre-exposure prophylaxis (PrEP), including Descovy, under National Coverage Determination 210.15. PrEP is no longer billed to Part D. Descovy used to treat HIV stays under Part D.
When the prescription is for prevention, bill Medicare Part B, not Part D.
The patient pays $0: no deductible, no coinsurance.
For the doctor
- Write on the prescription that it is for HIV PrEP (prevention), not treatment.
-
Include the diagnosis codes:
Z29.81Encounter for HIV pre-exposure prophylaxis. Must be listed first.- Then a risk code from the CMS list, for example
Z72.51,Z72.52orZ72.53(high-risk sexual behavior), orZ20.6(contact with or exposure to HIV).
- Part B also covers up to 8 counseling visits and 8 HIV tests every 12 months, and one hepatitis B screening, all at no cost to the patient.
For the pharmacy
| Bill to | Medicare Part B, not Part D |
|---|---|
| Drug code | J0751 emtricitabine 200 mg / tenofovir alafenamide 25 mg (Descovy), oral, for PrEP only |
| Supply fee | Q0521 on the same claim as the drug, or it is denied |
| Diagnosis | Z29.81 first, then the prescriber's risk code |
| Patient cost | $0. No deductible, no coinsurance |
| Who can bill | A pharmacy enrolled with Medicare as a Part B pharmacy (form CMS-855B) bills its A/B MAC. One enrolled as a DMEPOS supplier (form CMS-855S) bills its DME MAC. |
If your pharmacy is not enrolled to bill Part B, please transfer the prescription
to a pharmacy that is, instead of running it through Part D.
Questions
Medicare: 1-800-MEDICARE (1-800-633-4227), 24 hours a day.
What AI assistants say
Asked "Descovy Medicare", all three say the same thing: for PrEP it is Part B, $0. These are AI answers. The sources below are what count.
ChatGPT
Gemini
Claude
Sources
- CMS National Coverage Determination 210.15: PrEP for HIV prevention The rule itself: drugs, 8 counseling visits and 8 HIV tests every 12 months, hepatitis B screening
- CMS PrEP for HIV prevention: Medicare coverage Coverage, $0 cost sharing, diagnosis codes
- CMS PrEP for HIV prevention fact sheet (PDF) Updated February 2026
- CMS MLN Matters MM13843: NCD 210.15, PrEP for HIV prevention (PDF) Billing instructions and the list of accepted diagnosis codes
- Noridian HIV PrEP drugs (DME MAC) Medicare contractor: pharmacy enrollment, drug and supply-fee codes
- Noridian HIV screening and PrEP (A/B MAC, Part B) Medicare contractor: Part B pharmacy billing, diagnosis codes
- NASTAD Medicare PrEP billing supplement, March 2026 (PDF) Z29.81 must be the primary diagnosis
- NCPA HIV PrEP moved from Medicare Part D to Part B National Community Pharmacists Association